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REVIEW article

Front. Genet.
Sec. Genetics of Common and Rare Diseases
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1413500

Molecular Mechanisms and Genetic Factors Contributing to the Developmental Dysplasia of the Hip

Provisionally accepted
Xiaoming Zhao Xiaoming Zhao 1*Shuai Liu Shuai Liu 2*Zhonghua Yang Zhonghua Yang 3*Yong Li Yong Li 3*
  • 1 Other, Shenyang, China
  • 2 Criminal Investigation Police University of China, Shenyang, Liaoning Province, China
  • 3 Shengjing hospital of China Medical University, Shenyang, China

The final, formatted version of the article will be published soon.

    The most prevalent hip disease in neonates is developmental dysplasia of the hip (DDH). A timely and accurate diagnosis is required to provide the most effective treatment for pediatric patients with DDH. Heredity and gene variation have been the subject of increased attention and research worldwide as one of the factors contributing to the pathogenesis of DDH. Genome-wide association studies (GWAS), genome-wide linkage analyses (GWLA), and exome sequencing (ES) have identified variants in numerous genes and single-nucleotide polymorphisms (SNPs) as being associated with susceptibility to DDH in sporadic and DDH family patients.Furthermore, the DDH phenotype can be observed in animal models that exhibit susceptibility genes or loci, including variants in CX3CR1, KANSL1, and GDF5. The dentification of noncoding RNAs and de novo gene variants in patients with DDH-related syndrome has enhanced our understanding of the genes implicated in DDH. This article reviews the most recent molecular mechanisms and genetic factors that contribute to DDH.

    Keywords: Developmental dysplasia of the hip, susceptibility gene, single-nucleotide polymorphisms, CX3CR1, GDF5

    Received: 07 Apr 2024; Accepted: 16 Jul 2024.

    Copyright: © 2024 Zhao, Liu, Yang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaoming Zhao, Other, Shenyang, China
    Shuai Liu, Criminal Investigation Police University of China, Shenyang, 110854, Liaoning Province, China
    Zhonghua Yang, Shengjing hospital of China Medical University, Shenyang, China
    Yong Li, Shengjing hospital of China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.