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REVIEW article

Front. Genet.
Sec. Livestock Genomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1405588

Long Non-Coding RNA (LncRNA) and Epigenetic Factors: Their Role in Regulating the Adipocytes in Bovine

Provisionally accepted
Diba D. Jilo Diba D. Jilo Belete K. Abebe Belete K. Abebe *Jiangfang Wang Jiangfang Wang *Juntao Guo Juntao Guo *Anning Li Anning Li *Linsen Zan Linsen Zan *
  • College of Animal Science and Technology, Northwest A&F University, Xianyang, Shanxi Province, China

The final, formatted version of the article will be published soon.

    Investigating the involvement of long non-coding RNAs (lncRNAs) and epigenetic processes in bovine adipocytes can provide valuable new insights into controlling adipogenesis in livestock.Long non-coding RNAs have been associated with forming chromatin loops that facilitate enhancer-promoter interactions during adipogenesis, as well as regulating important adipogenic transcription factors like C/EBPα and PPARγ. They significantly influence gene expression regulation at the post-transcriptional level and are extensively researched for their diverse roles in cellular functions. Epigenetic modifications such as chromatin reorganization, histone alterations, and DNA methylation subsequently affect the activation of genes related to adipogenesis and the progression of adipocyte differentiation. By investigating how fat deposition is epigenetically regulated in beef cattle, scientists aim to unravel molecular mechanisms, identify key regulatory genes and pathways, and develop targeted strategies for modifying fat deposition to enhance desirable traits such as marbling and meat tenderness. This review paper delves into lncRNAs and epigenetic factors and their role in regulating bovine adipocytes while focusing on their potential as targets for genetic improvement to increase production efficiency. Recent genomics advancements, including molecular markers and genetic variations, can boost animal productivity, meeting global demands for high-quality meat products. This review establishes a foundation for future research on understanding regulatory networks linked to lncRNAs and epigenetic changes, contributing to both scholarly knowledge advancement and practical applications within animal agriculture.

    Keywords: Bovine adipocytes, epigenetic factors, LncRNAs function, regulation role, meat quality

    Received: 23 Mar 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Jilo, Abebe, Wang, Guo, Li and Zan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Belete K. Abebe, College of Animal Science and Technology, Northwest A&F University, Xianyang, 712100, Shanxi Province, China
    Jiangfang Wang, College of Animal Science and Technology, Northwest A&F University, Xianyang, 712100, Shanxi Province, China
    Juntao Guo, College of Animal Science and Technology, Northwest A&F University, Xianyang, 712100, Shanxi Province, China
    Anning Li, College of Animal Science and Technology, Northwest A&F University, Xianyang, 712100, Shanxi Province, China
    Linsen Zan, College of Animal Science and Technology, Northwest A&F University, Xianyang, 712100, Shanxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.