AUTHOR=Zhu Guandong , Tian Ruikang , Zhou Dengke , Qin Xuejiao 

TITLE=Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study

JOURNAL=Frontiers in Genetics

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1378802

DOI=10.3389/fgene.2024.1378802

ISSN=1664-8021

ABSTRACT=<sec><title>Purpose</title><p>To investigate the genetic correlation and causal links between sleep traits (including sleep duration, chronotype, and insomnia) and myopia.</p></sec><sec><title>Methods</title><p>Summary data on three sleep traits (sleep duration, chronotype and insomnia) and myopia from FinnGen (n = 214,211) and UK Biobank (n = 460,536) were analyzed using linkage disequilibrium score regression (LD Score), univariable and multivariable mendelian randomization (MR) experiments and Causal Analysis Using Summary Effect (CAUSE) estimation.</p></sec><sec><title>Results</title><p>LD Score regression detected candidate genetic correlation between sleep traits and myopia, such as sleep duration, chronotype (Genetic Correlation Z-score &gt;10.00, h2<italic>_</italic>observed_<italic>p</italic> &lt; 0.005, Lambda GC &gt; 1.05, <italic>p</italic> &gt; 0.05). Univariable MR analyses indicated that increased sleep duration has a promotional effect on the occurrence of myopia (<italic>p</italic> = 0.046 &lt; 0.05, P_FDR = 0.138 &lt; 0.2, OR = 2.872, 95% CI: 1.018–8.101). However, after accounting for potential confounding factors, multivariable MR and CAUSE analysis did not provide evidence for a causal effect of the three sleep traits on myopia.</p></sec><sec><title>Conclusion</title><p>There may be a potential genetic correlation between sleep duration, chronotype and myopia. However, neither of sleep duration, chronotype or insomnia had causal effect on myopia.</p></sec>