AUTHOR=Lin Chun-Nan , Ho Chien-Chang , Hsieh Pao-Chun , Hsiao Chih-Hsuan , Nfor Oswald Ndi , Liaw Yung-Po 

TITLE=Polymorphism rs3733591 of the SLC2A9 gene and metabolic syndrome affect gout risk in Taiwan Biobank subjects

JOURNAL=Frontiers in Genetics

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1374405

DOI=10.3389/fgene.2024.1374405

ISSN=1664-8021

ABSTRACT=<sec><title>Background:</title><p>Over the past few decades, gout and diseases like metabolic syndrome (MetS) have become more prevalent. Attempts have been made in Taiwan to identify the genes responsible for gout. A few gene loci, among them <italic>SLC2A9</italic>, have been identified using Taiwan Biobank (TWB) data. We, therefore, examined whether MetS could also account for the association between polymorphism <italic>SLC2A9</italic> rs3733591 and gout.</p></sec><sec><title>Methods:</title><p>The final analysis consisted of 73,558 subjects, of whom 2,709 had gout. To estimate the likelihood of gout occurrence based on rs3733591 and MetS, we used logistic regression models.</p></sec><sec><title>Results:</title><p>Rs3733591-TC + CC compared to TT genotype was associated with gout (OR, 1.15; 95% CI, 1.06–1.25). Also associated with gout was MetS (OR, 1.21; 95% CI, 1.10–1.33). A significant interaction was seen between rs3733591 and MetS (<italic>p</italic>-value = 0.039). Using rs3733591-TT/no MetS as the reference group, the ORs (95% CI) for gout was 1.24 (1.11–1.38) for TC + CC/no MetS, 1.35 (1.17–1.56) for TT/MetS, and 1.39 (1.22–1.58) for TC + CC/MetS. However, subgroup analysis defined by sex showed no significant associations in women.</p></sec><sec><title>Conclusion:</title><p>In summary, metabolic syndrome and <italic>SLC2A9</italic> rs3733591 genotypes were interactively associated with gout in Taiwanese men, but not women.</p></sec>