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ORIGINAL RESEARCH article

Front. Genet.
Sec. Statistical Genetics and Methodology
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1358288

Causal Associations between Sarcopenia Traits and Cognitive Impairment: A Bidirectional Mendelian Randomization Study

Provisionally accepted
Xiaole Sang Xiaole Sang *Hengfei Zhang Hengfei Zhang Heng Wang Heng Wang Yixu Xie Yixu Xie
  • Zhengzhou Central Hospital, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Observational studies had indicated an association between cognitive impairment and sarcopenia, but high-quality causal effect evidence remained lacking. The purpose of this study is to determine the causal relationship between cognitive impairment and sarcopenia through a bidirectional Mendelian randomization (MR) study.The inverse variance-weighted (IVW) method was employed as the primary analytical approach to assess causal relationships. Additionally, we conducted sensitivity analyses using MR-Egger and weighted median to complement the IVW results. Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) method was used for sensitivity analysis.IVW analysis revealed that walking pace showed causal effects on cognitive performance (OR = 2.171, 95% C.I.

    Keywords: cognitive impairment, Sarcopenia, muscle mass, Muscle Strength, physical performance, causal relationship, Mendelian randomization

    Received: 20 Dec 2023; Accepted: 28 Jun 2024.

    Copyright: © 2024 Sang, Zhang, Wang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaole Sang, Zhengzhou Central Hospital, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.