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REVIEW article

Front. Genet.
Sec. Human and Medical Genomics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1349717
This article is part of the Research Topic Biomarkers and Mechanisms of Gastrointestinal Diseases View all 3 articles

Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development

Provisionally accepted
Chia-Wei Cheng Chia-Wei Cheng 1,2*Jennifer Ho Jennifer Ho 2Nicholas Puoplo Nicholas Puoplo 2Namrata Pokharel Namrata Pokharel 2Aanya Hirdaramani Aanya Hirdaramani 2
  • 1 Columbia University, New York City, United States
  • 2 Columbia University Irving Medical Center, Columbia University, New York, New York, United States

The final, formatted version of the article will be published soon.

    Food-gene interaction has been identified as a leading risk factor for inflammatory bowel disease (IBD) and colorectal cancer (CRC). Accordingly, nutrigenomics emerges as a new approach to identify biomarkers and therapeutic targets for these two strongly associated gastrointestinal diseases. Recent studies in stem cell biology have further shown that diet and nutrition signal to intestinal stem cells (ISC) by altering nutrient-sensing transcriptional activities, thereby influencing barrier integrity and susceptibility to inflammation and tumorigenesis. This review recognizes the dietary factors related to both CRC and IBD and investigates their impact on the overlapping transcription factors governing stem cell activities in homeostasis and post-injury responses. Our objective is to provide a framework to study the food-gene regulatory network of diseasecontributing cells and inspire new nutrigenomic approaches for detecting and treating diet-related IBD and CRC.

    Keywords: Nutrigenomics, Intestinal Stem Cells, inflammatory bowel disease, colorectal cancer, Transcriptional regulation, food-gene interaction

    Received: 05 Dec 2023; Accepted: 12 Aug 2024.

    Copyright: © 2024 Cheng, Ho, Puoplo, Pokharel and Hirdaramani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chia-Wei Cheng, Columbia University, New York City, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.