AUTHOR=Yeo Nicholas Kim-Wah , Lim Che Kang , Yaung Katherine Nay , Khoo Nicholas Kim Huat , Arkachaisri Thaschawee , Albani Salvatore , Yeo Joo Guan 

TITLE=Genetic interrogation for sequence and copy number variants in systemic lupus erythematosus

JOURNAL=Frontiers in Genetics

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1341272

DOI=10.3389/fgene.2024.1341272

ISSN=1664-8021

ABSTRACT=<p>Early-onset systemic lupus erythematosus presents with a more severe disease and is associated with a greater genetic burden, especially in patients from Black, Asian or Hispanic ancestries. Next-generation sequencing techniques, notably whole exome sequencing, have been extensively used in genomic interrogation studies to identify causal disease variants that are increasingly implicated in the development of autoimmunity. This Review discusses the known casual variants of polygenic and monogenic systemic lupus erythematosus and its implications under certain genetic disparities while suggesting an age-based sequencing strategy to aid in clinical diagnostics and patient management for improved patient care.</p>