AUTHOR=Sullivan H. Cliff , Gandhi Manish J. , Gaitonde Sujata , Narasimhan Ramya , Gendzekhadze Ketevan , Pandey Soumya , Roby Rhonda K. , Maha George C. , Kaur Harmeet , Schiller Jennifer J. , McDowell Julie , Smith Maria , Liu Chang , Morris Gerald P. TITLE=Seventy-five years of service: an overview of the College of American Pathologists’ proficiency testing program in histocompatibility and identity testing JOURNAL=Frontiers in Genetics VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1331169 DOI=10.3389/fgene.2023.1331169 ISSN=1664-8021 ABSTRACT=

The Histocompatibility and Identity Testing Committee offers an overview of the College of American Pathologists’ (CAP) Proficiency Testing (PT) program, commemorating its significant 75th anniversary in 2024. The CAP PT program has undergone significant growth and evolution over the years, ultimately achieving Centers for Medicare and Medicaid Services approval. In 1979, CAP’s partnership with the American Association for Clinical Histocompatibility Testing marked a pivotal moment, leading to the creation of the first proficiency testing survey in 1980. This laid the foundation for various PT programs managed by the CAP Histocompatibility and Identity Testing Committee, including HLA antibody testing, HLA molecular typing, engraftment monitoring, parentage/relationship testing, HLA disease associations and drug risk, and HLA-B27 typing. Each program’s distinctive considerations, grading methodologies, and future prospects are detailed here, highlighting the continual evolution of histocompatibility and identity testing PT to support emerging technologies and evolving laboratory practices in the field.