AUTHOR=Al Othaim Ayoub , Al-Hawary Sulieman Ibraheem Shelash , Alsaab Hashem O. , Almalki Sami G. , Najm Mazin A. A. , Hjazi Ahmed , Alsalamy Ali , Firras Almulla Abbas , Alizadeh Hamzeh 

TITLE=Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis

JOURNAL=Frontiers in Genetics

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1280051

DOI=10.3389/fgene.2023.1280051

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> An increasing number of studies have suggested the relationship between single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes and gastric cancer (GC) susceptibility; however, the available evidence is contradictory. This meta-analysis aimed to comprehensively evaluate whether the SNPs within the TLR family are related to GC development.</p><p><bold>Methods:</bold> PubMed, Scopus, and China National Knowledge Infrastructure (CNKI) were systematically searched up to May 2023 to obtain the pertinent publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were applied to examine the associations using the random-effects model.</p><p><bold>Results:</bold> A total of 45 studies with 25,831 participants (cases: 11,308; controls: 14,523) examining the relation of 18 different SNPs in the TLR family to GC were analyzed. Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models. No significant association was detected for TLR-2-196 to -174de (Delta22), TLR-2 rs3804100, TLR-4 rs11536889, TLR-4 rs11536878, TLR-4 rs2770150, TLR-4 rs10116253, TLR-4 rs1927911, TLR-4 rs10983755, TLR-4 rs10759932, TLR-4 rs1927914, and TLR-10 rs10004195.</p><p><bold>Conclusion:</bold> These findings indicate that variations in TLR-4, TLR-5, and TLR-9 genes were found to be potential risk factors for GC.</p>