AUTHOR=Zhang Xia , Liu Rongfeng 

TITLE=Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population

JOURNAL=Frontiers in Genetics

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1212465

DOI=10.3389/fgene.2023.1212465

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Pyroptosis is essential for the remodeling of tumor immune microenvironment and suppression of tumor development. However, there is little information available about pyroptosis-related gene polymorphisms in non-small cell lung cancer (NSCLC).</p><p><bold>Methods:</bold> Six SNPs in the <italic>GSDMB</italic>, <italic>GSDMC</italic>, and <italic>AIM2</italic> were genotyped in 650 NSCLC cases and 650 healthy controls using a MassARRAY platform.</p><p><bold>Results:</bold> Minor alleles of rs8067378, rs2305480, and rs77681114 were associated with a lower risk of NSCLC (<italic>p</italic> &lt; 0.005), whereas rs2290400 and rs1103577 were related to an increased risk (<italic>p</italic> &lt; 0.00001). Moreover, rs8067378-AG/GG, rs2305480-GA/AA, and rs77681114-GA/AA genotypes were associated with a decrease in NSCLC risk (<italic>p</italic> &lt; 0.005). In contrast, the TC/CC genotypes of rs2290400 and rs1103577 were associated with an elevated NSCLC risk (<italic>p</italic> &lt; 0.0001). Based on the analysis of genetic models, minor alleles of rs8067378, rs2305480 and rs77681114 were related to reduced risk of NSCLC (<italic>p</italic> &lt; 0.05); whereas rs2290400 and rs1103577 were related to increased risk (<italic>p</italic> &lt; 0.01).</p><p><bold>Conclusion:</bold> Our findings provided new insights into the roles of pyroptosis-related genes in NSCLC, as well as new factors to be considered for assessing the risk of developing this cancer.</p>