AUTHOR=Han Xianfu , Lin Demin , Huang Weiwei , Li Dingpeng , Li Ning , Xie Xingwen 

TITLE=Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: A review of TCM intervention

JOURNAL=Frontiers in Genetics

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1159167

DOI=10.3389/fgene.2023.1159167

ISSN=1664-8021

ABSTRACT=<p><bold>Objective:</bold> This paper briefly reviews the structure and function of NLRP3 inflammasomes, signaling pathway, relationship with synovitis in KOA, and intervention of traditional Chinese medicine (TCM) in NLRP3 inflammasomes as a means to improve its therapeutic potential and clinical application.</p><p><bold>Method:</bold> Literatures about NLRP3 inflammasomes and synovitis in KOA were reviewed to analyze and discuss.</p><p><bold>Result:</bold> NLRP3 inflammasome can activate NF-κB mediated signal transduction, which in turn causes the expression of proinflammatory cytokines, initiates the innate immune response, and triggers synovitis in KOA. The TCM monomer/active ingredient, decoction, external ointment, and acupuncture regulating NLRP3 inflammasomes are helpful to alleviate synovitis in KOA.</p><p><bold>Conclusion:</bold> The NLRP3 inflammasome plays a significant role in the pathogenesis of synovitis in KOA, TCM intervention targeting the NLRP3 inflammasome can be a novel approach and therapeutic direction for the treatment of synovitis in KOA.</p>