AUTHOR=Cao Maolin , Zhang Yifei , Chen Dan , Zhong Jiaju , Zhang Xiaoli , Yang Ling , Li Xue , Fang Liang , Liu Beizhong , Gong Fang , Zhou Chanjuan 

TITLE=Polymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population

JOURNAL=Frontiers in Genetics

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1056186

DOI=10.3389/fgene.2023.1056186

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Dyslipidemia is an independent predictor of ischemic stroke (IS). Genetic variations in lipid-metabolism related genes may increase the risk of IS. Fatty acid-binding protein 1 (FABP1) and fatty acid-binding protein 2 (FABP2) are lipid chaperones responsible for lipid transport and metabolism. The present study aimed to determine the association between <italic>FABP1</italic> or <italic>FABP2</italic> and ischemic stroke.</p><p><bold>Methods:</bold> A total of 251 participants were recruited composed of 138 patients with ischemic stroke and 113 healthy subjects. DNA was extracted from peripheral blood samples. The rs2241883 polymorphism in <italic>FABP1</italic> and rs1799883 polymorphism in <italic>FABP2</italic> were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between two SNPs and environmental factors.</p><p><bold>Results:</bold> The GA genotype of FABP2 rs1799883 increased susceptibility to ischemic stroke under overdominant inheritance model (<italic>p</italic> = 0.042). After adjusting for the risk factors of IS, it was associated with a significantly higher risk of IS in the codominant inheritance model (adjust OR = 3.431, 95%CI = 1.060–11.103, <italic>p</italic> = 0.04). The interactions of <italic>FABP1</italic> rs2241883 and <italic>FABP2</italic> rs1799883 were not associated with IS risk (<italic>p</italic> = 0.172). Moreover, interaction analysis of two genes (rs1799883 and rs2241883) and two environmental factors (smoking and alcohol consumption) was associated with an increased risk of IS (<italic>p</italic> = 0.011).</p><p><bold>Conclusion:</bold> The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations.</p>