AUTHOR=Chen Chunli , Guo Sitong , Zhao Rui , Liu Shoubin , Wu Jingjing , Xiao Yuanyuan , Hou Simeng , Jiang Libin 

TITLE=A boy with amblyopia and familial exudative vitreoretinopathy harboring a new mutation of LRP5 and OPA1: A case report

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.998846

DOI=10.3389/fgene.2022.998846

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> The study aimed to report a boy with familial exudative vitreoretinopathy and amblyopia harboring a new mutation of the <italic>LRP5</italic> and <italic>OPA1</italic> gene abnormality.</p><p><bold>Case presentation</bold>: A 9-year-old boy presented with a 2-year history of deteriorating visual acuity in the right eye. His best-corrected visual acuity was −7.00/−1.75 × 100 = 0.3 in the right eye and −2.50/−1.50 × 170 = 0.8 in the left eye. Two autosomal dominant gene mutation sites were identified in the patient: <italic>LRP5</italic> (c.2551C &gt; T, <italic>p</italic>.His851Tyr) from his father and <italic>OPA1</italic> (c.565G &gt; A, <italic>p</italic>.Glu189Lys) from his mother. Interestingly, his fraternal twin brother harbored no abnormal gene mutations, and his eye tests were normal.</p><p><bold>Conclusion:</bold> This case expands the spectrum of <italic>LRP5</italic> gene mutations among Chinese patients with familial exudative vitreoretinopathy, and it is the first time to report a patient harboring both LRP5 and OPA1 gene mutations having anisometropic amblyopia and strabismus as the primary manifestations. These four family members exhibited individual heterogeneity of phenotypes and genotypes associated with hereditary ophthalmopathy. A comprehensive analysis of clinical phenotypes and genotypes provides clinical clues for improving the level of clinical and genetic diagnoses and a deeper understanding of the disease.</p>