AUTHOR=Pizzul Paolo , Casari Erika , Gnugnoli Marco , Rinaldi Carlo , Corallo Flavio , Longhese Maria Pia 

TITLE=The DNA damage checkpoint: A tale from budding yeast

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.995163

DOI=10.3389/fgene.2022.995163

ISSN=1664-8021

ABSTRACT=<p>Studies performed in the yeasts <italic>Saccharomyces cerevisiae</italic> and <italic>Schizosaccharomyces pombe</italic> have led the way in defining the DNA damage checkpoint and in identifying most of the proteins involved in this regulatory network, which turned out to have structural and functional equivalents in humans. Subsequent experiments revealed that the checkpoint is an elaborate signal transduction pathway that has the ability to sense and signal the presence of damaged DNA and transduce this information to influence a multifaceted cellular response that is essential for cancer avoidance. This review focuses on the work that was done in <italic>Saccharomyces cerevisiae</italic> to articulate the checkpoint concept, to identify its players and the mechanisms of activation and deactivation.</p>