AUTHOR=Caetano-Anollés Gustavo , Janko Richard TITLE=The rise of hierarchy and modularity in biological networks explained by Empedocles’ double tale ∼2,400 years before Darwin and systems biology JOURNAL=Frontiers in Genetics VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.973233 DOI=10.3389/fgene.2022.973233 ISSN=1664-8021