AUTHOR=Li Yuting , Fan Honghong , Ding Junli , Xu Junying , Liu Chaoying , Wang Huiyu TITLE=Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization JOURNAL=Frontiers in Genetics VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.969723 DOI=10.3389/fgene.2022.969723 ISSN=1664-8021 ABSTRACT=

With continued advances in cancer research, the crucial role of the tumor microenvironment (TME) in regulating tumor progression and influencing immunotherapy outcomes has been realized over the years. A series of studies devoted to enhancing the response to immunotherapies through exploring efficient predictive biomarkers and new combination approaches. The microfluidic technology not only promoted the development of multi-omics analyses but also enabled the recapitulation of TME in vitro microfluidic system, which made these devices attractive across studies for optimization of immunotherapy. Here, we reviewed the application of microfluidic systems in modeling TME and the potential of these devices in predicting and monitoring immunotherapy effects.