AUTHOR=Chen Hui-Ming , Li Hang , Lin Meng-Xian , Fan Wei-Jie , Zhang Yi , Lin Yan-Ting , Wu Shu-Xiang 

TITLE=Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.952667

DOI=10.3389/fgene.2022.952667

ISSN=1664-8021

ABSTRACT=<p>As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by leaps and bounds, the association of RNA modifications with multiple human diseases sparked research enthusiasm; in addition, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focused on RNA modifications (N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), N<sup>5</sup>-methylcytosine (m<sup>5</sup>C), N<sup>7</sup>-methylguanosine (m<sup>7</sup>G), N<sup>1</sup>-methyladenosine (m<sup>1</sup>A), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis to emphasize the role and impact of RNA modifications.</p>