AUTHOR=Greising Sarah M. , Weiner Joshua I. , Garry Daniel J. , Sachs David H. , Garry Mary G. 

TITLE=Human muscle in gene edited pigs for treatment of volumetric muscle loss

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.948496

DOI=10.3389/fgene.2022.948496

ISSN=1664-8021

ABSTRACT=<p>Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.</p>