AUTHOR=Yang Min , Pang Bo , Wang Qiong , Zhang Zhixin , Niu Wenquan 

TITLE=The causal association between genetically regulated 25OHD and chronic obstructive pulmonary disease: A meta-analysis and Mendelian randomization study

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.932764

DOI=10.3389/fgene.2022.932764

ISSN=1664-8021

ABSTRACT=<p><bold>Backgrounds and objectives:</bold> Chronic obstructive pulmonary disease (COPD) is a multifactorial disease under genetic control. We present a meta-analysis to examine the associations of vitamin D binding protein (<italic>VDBP</italic>) gene rs7041 polymorphism with the risk of COPD and changes in circulating 25OHD concentrations.</p><p><bold>Methods:</bold> A literature search, quality assessment, and data extraction were conducted independently by two investigators. Data are expressed as odds ratio (OR) or weighted mean difference (WMD) with a 95% confidence interval (CI). The inverse variance weighted method (IVW) in R (version 1.1.456) was applied to calculate the Mendelian randomization coefficient.</p><p><bold>Results:</bold> A total of 13 articles with 3,667 participants were meta-analyzed. The rs7041-GT genotype was associated with a 49% reduced COPD risk (OR: 0.51, 95% CI: 0.30 to 0.88, <italic>p</italic> = 0.014) compared to the rs7041-TT genotype. Carriers of the rs7041-GT genotype had significantly higher concentrations of circulating 25OHD than those with the rs7041-TT genotype (WMD: 0.32 ng/ml, 95% CI: 0.09 to 0.55, <italic>p</italic> = 0.006). Under the assumptions of Mendelian randomization, and assuming a linear logistic relationship between circulating 25OHD and COPD, an inverse association was noted after using <italic>VDBP</italic> gene rs7041 polymorphism as an instrument (WMD: −2.07, 95% CI: −3.72 to −0.41, <italic>p</italic> = 0.015). There was a low probability of publication bias.</p><p><bold>Conclusion:</bold> We observed significant associations of <italic>VDBP</italic> gene rs7041 polymorphism with the risk of COPD and changes in circulating 25OHD concentrations. Importantly, we found a causal relationship between genetically regulated 25OHD concentrations and COPD risk.</p>