AUTHOR=Awal Md Abdul , Nur Suza Mohammad , Al Khalaf Ali Khalaf , Rehan Mohd , Ahmad Aamir , Hosawi Salman Bakr I. , Choudhry Hani , Khan Mohammad Imran TITLE=Structural-Guided Identification of Small Molecule Inhibitor of UHRF1 Methyltransferase Activity JOURNAL=Frontiers in Genetics VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.928884 DOI=10.3389/fgene.2022.928884 ISSN=1664-8021 ABSTRACT=
Ubiquitin-like containing plant homeodomain Ring Finger 1 (UHRF1) protein is recognized as a cell-cycle-regulated multidomain protein. UHRF1 importantly manifests the maintenance of DNA methylation mediated by the interaction between its SRA (SET and RING associated) domain and DNA methyltransferase-1 (DNMT1)-like epigenetic modulators. However, overexpression of UHRF1 epigenetically responds to the aberrant global methylation and promotes tumorigenesis. To date, no potential molecular inhibitor has been studied against the SRA domain. Therefore, this study focused on identifying the active natural drug-like candidates against the SRA domain. A comprehensive set of