AUTHOR=Wang Yongfeng , Jiang Xianglai , Zhang Dongzhi , Zhao Yuanbin , Han Xiaoyong , Zhu Lihui , Ren Jingyao , Liu Yubin , You Jiarong , Wang Haolan , Cai Hui 

TITLE=LncRNA DUXAP8 as a prognostic biomarker for various cancers: A meta-analysis and bioinformatics analysis

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.907774

DOI=10.3389/fgene.2022.907774

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Dual homeoboxes A pseudogene 8 (<italic>DUXAP8</italic>) is a newly discovered long noncoding RNA that has been shown to function as an oncogene in a variety of human malignant cancers. By integrating available data, this meta-analysis sought to determine the relationship between clinical prognosis and <italic>DUXAP8</italic> expression levels in diverse malignancies.</p><p><bold>Materials and methods:</bold> A systematic search was performed to identify eligible studies from several electronic databases from their inception to 25 October 2021. Pooled odds ratios and hazard ratios with 95% CI were used to estimate the association between <italic>DUXAP8</italic> expression and survival. For survival analysis, the Kaplan-Meier method and COX analysis were used. Furthermore, we utilized Spearman’s correlation analysis to explore the correlation between <italic>DUXAP8</italic> and tumor mutational burden (TMB), microsatellite instability (MSI), the related genes of mismatch repair (MMR), DNA methyltransferases (DNMTs), and immune checkpoint biomarkers.</p><p><bold>Results:</bold> Our findings indicated that overexpression of <italic>DUXAP8</italic> was related to poor overall survival (OS) (HR = 1.63, 95% CI, 1.49–1.77, <italic>p</italic> &lt; 0.001). In addition, elevated <italic>DUXAP8</italic> expression was closely related to poor OS in several cancers in the TCGA database. Moreover, <italic>DUXAP8</italic> expression has been associated with TMB, MSI, and MMR in a variety of malignancies.</p><p><bold>Conclusion:</bold> This study revealed that <italic>DUXAP8</italic> might serve as a prognostic biomarker and potential therapeutic target for cancer. It can be used to improve cancer diagnosis, discover potential treatment targets, and improve prognosis.</p>