AUTHOR=Hu Baoping , Wang Yuhe , Wang Zhongtao , He Xue , Wang Li , Yuan Dongya , He Yongjun , Jin Tianbo , He Shumei 

TITLE=Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.899124

DOI=10.3389/fgene.2022.899124

ISSN=1664-8021

ABSTRACT=<p>Tuberculosis (TB) is an important health issue in the world. Although the relation of <italic>SLC11A1</italic> polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorphisms in or near the <italic>SLC11A1</italic> gene and susceptibility to TB. The Agena MassARRAY platform was conducted for genotyping from 510 TB patients and 508 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed through logistic regression adjustment age and gender to assess the relationships between polymorphisms and TB risk. Our results identified that rs7608307 was related to increased TB risk in males (CT vs. CC: OR = 1.69, 95%CI: 1.12–2.56, <italic>p</italic> = 0.013; CT-TT vs. CC: OR = 1.61, 95%CI: 1.08–2.41, <italic>p</italic> = 0.020) and age ≤41 group (CT vs. CC: OR = 1.66, 95%CI: 1.04–2.65, <italic>p</italic> = 0.035), respectively. The SNP rs13062 was associated with the TB risk both in males (<italic>p</italic> = 0.012) and age &gt;41 group (<italic>p</italic> = 0.021). In addition, we observed that the CC genotype of rs4674301 was correlated with increased TB risk in females (<italic>p</italic> = 0.043). Our results demonstrated the relationships between polymorphisms (rs7608307, rs4674301, and rs13062) in or near the <italic>SLC11A1</italic> gene and age- and sex-specific TB risk in the northwest Chinese Han population.</p>