AUTHOR=Wei Cuie , Sun Wentao , Liu Changhai , Meng Fanjun , Sun Lele , Ding Xiangsheng 

TITLE=Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.897440

DOI=10.3389/fgene.2022.897440

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> To elucidate the potential biological function of hsa_circ_0062270 in the malignant process of melanoma and its potential target.</p><p><bold>Methods:</bold> Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to examine relative level of hsa_circ_0062270 in melanoma tissues and normal skin tissues. The diagnostic and prognostic potentials of hsa_circ_0062270 in melanoma were evaluated. The regulatory effect of hsa_circ_0062270 on the expression of linear transcript Cell division cycle protein 45 (CDC45) was also examined.</p><p><bold>Results:</bold> Hsa_circ_0062270 was up-regulated in melanoma samples and cell lines, which displayed certain diagnostic and prognostic potentials in melanoma. Inhibition of hsa_circ_0062270 attenuated the proliferative, migratory and invasive functions. Hsa_circ_0062270 could stabilize the expression of linear transcript CDC45, and thus participated in the malignant process of melanoma.</p><p><bold>Conclusion:</bold> Hsa_circ_0062270 promotes proliferative, migratory and invasive functions of melanoma cells <italic>via</italic> stabilizing the linear transcript CDC45. Hsa_circ_0062270 can be used to diagnosis and treatment of melanoma.</p>