AUTHOR=Gjorgjievska Marija , Mehandziska Sanja , Stajkovska Aleksandra , Pecioska-Dokuzovska Slavica , Dimovska Anica , Durmish Idriz , Ismail Sara , Pavlovska Teodora , Stojchevska Antonija , Amedi Haris , Andonova Jasna , Nikolovska Marija , Velickovikj Sara , Mitrev Zan , Kungulovski Ivan , Kungulovski Goran 

TITLE=Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.892682

DOI=10.3389/fgene.2022.892682

ISSN=1664-8021

ABSTRACT=<p>Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host.</p>