AUTHOR=Wei Li , Xia Shutao , Li Yifei , Qi Yan , Wang Yue , Zhang Donghui , Hua Yimin , Luo Shuhua 

TITLE=Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.891159

DOI=10.3389/fgene.2022.891159

ISSN=1664-8021

ABSTRACT=<p>Human induced pluripotent stem cells (hIPSC) have been used to produce almost all types of human cells currently, which makes them into several potential applications with replicated patient-specific genotype. Furthermore, hIPSC derived cardiomyocytes assembled engineering heart tissue can be established to achieve multiple functional evaluations by tissue engineering technology. This short review summarized the current advanced applications based on the hIPSC derived heart tissue in molecular mechanisms elucidating and high throughput drug screening.</p>