AUTHOR=Chuang Chih-Chun , Yang Yi-Sun , Kornelius Edy , Huang Chien-Ning , Hsu Min-Yen , Lee Chia-Yi , Yang Shun-Fa 

TITLE=Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.889530

DOI=10.3389/fgene.2022.889530

ISSN=1664-8021

ABSTRACT=<p>Long noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 (<italic>LINC00673</italic>) affects the clinical characteristics of diabetic retinopathy (DR). A total of three loci of <italic>LINC00673</italic> SNPs (rs6501551, rs9914618, and rs11655237) were genotyped using TaqMan allelic discrimination in 276 and 454 individuals with and without DR, respectively. Our results revealed that <italic>LINC00673</italic> SNP rs11655237 CT genotype (AOR: 1.592, 95% CI: 1.059–2.395, <italic>p</italic> = 0.026), CT + TT genotype (AOR: 1.255, 95% CI: 1.029–1.531, <italic>p</italic> = 0.025), and allele T (AOR: 1.185, 95% CI: 1.004–1.397, <italic>p</italic> = 0.044) yielded higher ratios in the non-proliferative diabetic retinopathy (NPDR) subgroup than in the non-DR group. Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the <italic>LINC00673</italic> SNP rs11655237 CT + TT variant than that in the <italic>LINC00673</italic> SNP rs11655237 wild type (10.44 ± 7.10 vs. 12.98 ± 8.34, <italic>p</italic> = 0.009). In conclusion, the <italic>LINC00673</italic> SNP rs11655237 T allele is associated with a higher probability of NPDR development. Patients with the <italic>LINC00673</italic> SNP rs11655237 CT + TT variant exhibited a short DM interval.</p>