AUTHOR=Lai Dong , Wang Lei , Li Jia-Rui , Chen Chen , Zhao Wen-Lei , Yuan Qing , Ma Xin , Zhang Xu TITLE=Transcriptional progressive patterns from mild to severe renal ischemia/reperfusion-induced kidney injury in mice JOURNAL=Frontiers in Genetics VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.874189 DOI=10.3389/fgene.2022.874189 ISSN=1664-8021 ABSTRACT=
The renal ischemia/reperfusion (I/R)-induced acute kidney injury incidence after nephron-sparing surgery for localized renal tumors is 20%, but the biological determinant process of postoperative acute kidney injury remains unclear. Using Gene Expression Omnibus database (GSE192883) and several bioinformatics analyses (discrete time points analysis, gene set enrichment analysis, dynamic network biomarker analysis, etc), combined with the establishment of the I/R model for verification, we identified three progressive patterns involving five core pathways confirmed using gene set enrichment analysis and six key genes (