AUTHOR=Yang Ying , Xiao Jingxin , Tang Lingling , Wang Bohan , Sun Xianhong , Xu Zhongchi , Liu Li , Shi Suofang 

TITLE=Effects of IL-6 Polymorphisms on Individual Susceptibility to Allergic Diseases: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.822091

DOI=10.3389/fgene.2022.822091

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Many studies have assessed the potential link between <italic>interleukin-6</italic> polymorphisms and susceptibility to allergic diseases. However, the results are still conflicting. Therefore, a comprehensive meta-analysis can not only resolve differences but also provide clues for future projects.</p><p><bold>Methods:</bold> A systematic electronic search was conducted on the databases of Web of Science, PubMed, and Cochrane Library to retrieve all published studies. Revman and Stata software were used for statistical analysis.</p><p><bold>Results:</bold> This meta-analysis included 11 studies. The results revealed that there was a statistically significant association between <italic>IL-6</italic> rs1800795 polymorphism and the risk of asthma and allergic rhinitis in the general population. Subgroup analyses demonstrated that rs1800795 affected allergic diseases risk in different populations.</p><p><bold>Conclusion:</bold> Our findings suggested that <italic>IL-6</italic> rs1800795 was associated with allergic diseases susceptibility among Asians and Caucasians in opposite trends, and it might influence the risk of asthma and allergic rhinitis. None of the <italic>IL-6</italic> polymorphisms were shared risk variants of allergic diseases.</p>