AUTHOR=Zhang Guoshun , Shang Hua , Liu Bin , Wu Guikai , Wu Diyang , Wang Liuqing , Li Shengnan , Wang Zhiyuan , Wang Suying , Yuan Juxiang 

TITLE=Increased ATP2A1 Predicts Poor Prognosis in Patients With Colorectal Carcinoma

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.661348

DOI=10.3389/fgene.2022.661348

ISSN=1664-8021

ABSTRACT=<p>Colorectal cancer is one of the most common malignant tumors in the digestive system. Traditional diagnosis and treatment methods have not significantly improved the overall survival of patients. In this study, we explored the value of <italic>ATP2A1</italic> as a biomarker in predicting the prognosis of colorectal cancer patients. We used the TCGA database to reveal the relationship between <italic>ATP2A1</italic> mRNA level and prognosis, methylation, and immune invasion in colorectal cancer. The results showed that the expression of <italic>ATP2A1</italic> was increased in colorectal cancer. The overall survival of patients with high expression of <italic>ATP2A1</italic> was significantly lower than patients with low expression of <italic>ATP2A1</italic>. Cox regression analysis showed that high expression of <italic>ATP2A1</italic> was an independent risk factor for poor prognosis in colorectal cancer patients. In addition, we used three datasets to perform a meta-analysis, which further confirmed the reliability of the results. Furthermore, we revealed that <italic>ATP2A1</italic> could significantly inhibit the proliferation of colorectal cancer cells by inhibiting the autophagy process and was associated with several immune cells, especially CD8 + T cells. Finally, four small molecule drugs with potential inhibition of <italic>ATP2A1</italic> expression were found by CMap analysis. This study demonstrates for the first time that <italic>ATP2A1</italic> is a potential pathogenic factor, which may play a significant role in colorectal cancer.</p>