AUTHOR=Li Jing , Qiu Chang-Yu , Tao Yue-Jin , Cheng Lei 

TITLE=Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1089647

DOI=10.3389/fgene.2022.1089647

ISSN=1664-8021

ABSTRACT=<p>Chronic rhinosinusitis (CRS) has brought a huge socioeconomic burden. However, its mechanism is still elusive, which may involve genetic, environmental and some other factors. Epigenetic analyses have been conducted to explore the mechanisms underlying CRS. Here, we reviewed the fruits in the epigenetic studies on DNA methylation, histone modification, and non-coding RNA regulation. We concluded that the epigenetic research on CRS has made great breakthroughs, especially in the past 5 years and the field of microRNAs. “Epigenetic therapies” are expected to be designed to treat CRS in the future.</p>