AUTHOR=Li Yu , Wu Chunyan , Ge Yingnan , Chen Xi , Zhu Li , Chu Ling , Wang Jia , Yan Meiling , Deng Hao 

TITLE=Identification of a nucleotide metabolism-related signature to predict prognosis and guide patient care in hepatocellular carcinoma

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1089291

DOI=10.3389/fgene.2022.1089291

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Hepatocellular carcinoma is a highly malignant tumor with significant heterogeneity. Metabolic reprogramming plays an essential role in the progression of hepatocellular carcinoma. Among them, nucleotide metabolism needs further investigation.</p><p><bold>Methods:</bold> Based on the bioinformatics approach, eleven prognosis-related nucleotide metabolism genes of hepatocellular carcinoma were screened in this study. Based on the Lasso-Cox regression method, we finally identified a prognostic model containing six genes and calculated the risk score for each patient. In addition, a nomogram was constructed on the basis of pathological stage and risk score.</p><p><bold>Results:</bold> Patients with high-risk score had worse prognosis than those with low-risk. The predictive efficiency of the model was efficient in both the TCGA dataset and the ICGC dataset. The risk score is an independent prognostic factor that can be used to screen chemotherapy drugs. In addition, the risk score can be useful in guiding patient care at an early stage.</p><p><bold>Conclusion:</bold> Nucleotide metabolism-related prognostic model can more accurately predict the prognosis of patients with hepatocellular carcinoma. As a novel prediction model, it is expected to help clinical staff to provide targeted treatment and nursing to patients.</p>