AUTHOR=Xie Hui , Wang Liushun , Tang Yihu , Zhao Meng , Wang Zihao , Liu Mingzhu , Zhao Quangong , Zhou Jingxin , Wu Yanhu 

TITLE=Functional analysis of differently expressed ferroptosis-related genes in patients with mitral valve prolapse

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1062212

DOI=10.3389/fgene.2022.1062212

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> The prevalence of mitral valve prolapse (MVP) in heart valvular diseases is globally increasing. However, the understanding of its etiology and pathogenesis is limited. So far, the relationship between ferroptosis-related genes and long non-coding RNAs (lncRNAs) in MVP remains unexplored. This study investigates the potential pathogenesis of ferroptosis-related genes in MVP and provides a therapeutic target for the disease.</p><p><bold>Methods:</bold> Blood samples from patients with MVP and healthy volunteers were collected for transcriptomic sequencing to analyze the expression of ferroptosis-related differentially expressed genes (DEGs) and differentially expressed long non-coding RNAs (DElncRNAs Co-expression network of ferroptosis-related DEGs and DElncRNAs. Furthermore, this work conducted GO and KEGG enrichment analyses.</p><p><bold>Results:</bold><italic>CDKN2A</italic>, <italic>SLC1A4</italic>, <italic>ATF3,</italic> and other core genes related to the mitral valve prolapse were screened out. <italic>CDKN2A</italic>, <italic>SLC1A4,</italic> and <italic>ATF3</italic> genes were at the core position of the network, regulated by numerous lncRNAs. Notably, these genes are primarily involved in the extracellular region and p53 signaling pathway.</p><p><bold>Conclusion:</bold> In summary, <italic>CDKN2A</italic>, <italic>SLC1A4</italic>, and <italic>ATF3</italic> regulate the pathophysiological process of MVP and are potential therapeutic targets.</p>