AUTHOR=Xiang Yuan , Fang Shi-Qiang , Liu Yi-Wen , Wang Hui , Lu Zhong-Xin 

TITLE=A rare case report of waldenström macroglobulinemia converted to serum low IgM

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1051917

DOI=10.3389/fgene.2022.1051917

ISSN=1664-8021

ABSTRACT=<p>Waldenström Macroglobulinemia (WM) is a rare chronic lymphoproliferative disease, accounting for less than 2% of hematological malignancies. It is characterized by plasma cytoid lymphocyte infiltration in bone marrow and abnormal increase of monoclonal IgM in peripheral blood. Only 5%–10% of cases of WM secrete monoclonal IgG and IgA components or do not secrete monoclonal long immunoglobulin. This case is the first to report of serum protein recombination from lgM and Igkappa band mutation to abnormal lgG and Igkappa band after 6 years of treatment in a male patient with WM.</p>