AUTHOR=Wei Wan , Xuan Xianjun , Zhu Jiahui , Chen Tianwen , Fang Yudan , Ding Jiao , Ji Danfei , Zhou Guoyi , Tang Bo , He Xudong 

TITLE=EDNRA Gene rs1878406 Polymorphism is Associated With Susceptibility to Large Artery Atherosclerotic Stroke

JOURNAL=Frontiers in Genetics

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.783074

DOI=10.3389/fgene.2021.783074

ISSN=1664-8021

ABSTRACT=<p><bold>Objective:</bold> We performed this study to investigate whether the EDNRA gene rs1878406 C &gt; T polymorphism is associated with risk of large artery atherosclerosis (LAA) stroke in the Chinese Han population.</p><p><bold>Methods:</bold> Genotyping of rs1878406 was performed in 1,112 LAA stroke patients and 1,192 healthy controls. Multivariate logistic regression analyses were applied to assess the effect of the rs1878406 C &gt; T polymorphism on susceptibility to LAA stroke.</p><p><bold>Results:</bold> A significant increase of LAA stroke risk was found in the recessive model (TT vs. CC/TC, OR = 1.74, 95% CI = 1.23–2.48, <italic>p</italic> = 0.002) and co-dominant model (TC vs. CC, OR = 1.06, 95% CI = 0.89–1.27, TT vs. CC, OR = 1.79, 95% CI = 1.25–2.55, <italic>p</italic> = 0.006). However, the interaction between age and genotypes of rs1878406 was not statistically significant, and no significant interactive effect was observed between the rs1878406 C &gt; T polymorphism and sex (<italic>p</italic> &gt; 0.05).</p><p><bold>Conclusion:</bold> The rs1878406 C &gt; T polymorphism is associated with increased risk of LAA stroke in the Chinese Han population.</p>