AUTHOR=Douillard Venceslas , Castelli Erick C. , Mack Steven J. , Hollenbach Jill A. , Gourraud Pierre-Antoine , Vince Nicolas , Limou Sophie ,  for the Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium 

TITLE=Current HLA Investigations on SARS-CoV-2 and Perspectives

JOURNAL=Frontiers in Genetics

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.774922

DOI=10.3389/fgene.2021.774922

ISSN=1664-8021

ABSTRACT=<p>The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA &amp; Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of <italic>HLA</italic> immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.</p>