AUTHOR=Marjonen Heidi , Marttila Minttu , Paajanen Teemu , Vornanen Marleena , Brunfeldt Minna , Joensuu Anni , Halmesvaara Otto , Aro Kimmo , Alanne-Kinnunen Mervi , Jousilahti Pekka , Borodulin Katja , Koskinen Seppo , Tuomi Tiinamaija , Ilanne-Parikka Pirjo , Lindström Jaana , Laine Merja K. , Auro Kirsi , Kääriäinen Helena , Perola Markus , Kristiansson Kati 

TITLE=A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

JOURNAL=Frontiers in Genetics

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.763159

DOI=10.3389/fgene.2021.763159

ISSN=1664-8021

ABSTRACT=<p>We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.</p>