AUTHOR=Liu Fuqiang , Wang Shengping , Luo Zhi 

TITLE=Associations of the miRNA-146a rs2910164 and the miRNA-499a rs3746444 Polymorphisms With Plasma Lipid Levels: A Meta-Analysis

JOURNAL=Frontiers in Genetics

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.746686

DOI=10.3389/fgene.2021.746686

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> The studies of miRNAs are vibrant and remain at the forefront in the cardiovascular system. Emerging studies indicate that the genetic polymorphisms of the <italic>miRNA</italic> gene may affect lipid metabolism; this study aims to clarify the specific correlations between the rs2910164 and rs3746444 polymorphisms and lipid levels.</p><p><bold>Methods and Results:</bold> A comprehensive search of literature was performed from December 31, 2020, to May 31, 2021, by searching of the PubMed and the Cochrane databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the differences in lipid levels between the genotypes. rs2910164, a functional polymorphism in the <italic>miRNA-146a</italic> gene, was associated with increased triglycerides (TG) (SMD = 0.35, 95% CI = 0.15–0.54, <italic>p</italic> &lt; 0.001), total cholesterol (TC) (SMD = 0.43, 95% CI = 0.16–0.70, <italic>p</italic> &lt; 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.37, 95% CI = 0.11–0.63, <italic>p</italic> = 0.01) as well as decreased high-density lipoprotein cholesterol (HDL-C) (SMD = −0.27, 95% CI = −0.47−0.07, <italic>p</italic> = 0.01) levels. rs3746444, a functional polymorphism in the <italic>miRNA-499a</italic> gene, was only correlated with decreased TG (SMD = −0.09, 95% CI = −0.17−0.01, <italic>P</italic> = 0.03) levels.</p><p><bold>Conclusions:</bold> The <italic>miRNA-146a</italic> rs2910164 polymorphism is significantly associated with atherogenic dyslipidemia.</p>