AUTHOR=Bensenor Isabela , Padilha Kallyandra , Lima Isabella Ramos , Santos Raul Dias , Lambert Gilles , Ramin-Mangata Stéphane , Bittencourt Marcio S , Goulart Alessandra C , Santos Itamar S. , Mill Jose G , Krieger Jose E , Lotufo Paulo A. , Pereira Alexandre C. TITLE=Genome-Wide Association of Proprotein Convertase Subtilisin/Kexin Type 9 Plasma Levels in the ELSA-Brasil Study JOURNAL=Frontiers in Genetics VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.728526 DOI=10.3389/fgene.2021.728526 ISSN=1664-8021 ABSTRACT=
Pharmacological inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) is an established therapeutic option to treat hypercholesterolemia, and plasma PCSK9 levels have been implicated in cardiovascular disease incidence. A number of genetic variants within the PCSK9 gene locus have been shown to modulate PCSK9 levels, but these only explain a very small percentage of the overall PCSK9 interindividual variation. Here we present data on the genetic association structure between PCSK9 levels and genom-wide genetic variation in a healthy sample from the general population. We performed a genome-wide association study of plasma PCSK9 levels in a sample of Brazilian individuals enrolled in the Estudo Longitudinal de Saude do Adulto cohort (