AUTHOR=Serranito Bruno , Taurisson-Mouret Dominique , Harkat Sahraoui , Laoun Abbas , Ouchene-Khelifi Nadjet-Amina , Pompanon François , Benjelloun Badr , Cecchi Giuliano , Thevenon Sophie , Lenstra Johannes A. , Da Silva Anne TITLE=Search for Selection Signatures Related to Trypanosomosis Tolerance in African Goats JOURNAL=Frontiers in Genetics VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.715732 DOI=10.3389/fgene.2021.715732 ISSN=1664-8021 ABSTRACT=
Livestock is heavily affected by trypanosomosis in Africa. Through strong selective pressure, several African indigenous breeds of cattle and small ruminants have acquired varying degrees of tolerance against this disease. In this study, we combined LFMM and PCAdapt for analyzing two datasets of goats from West-Central Africa and East Africa, respectively, both comprising breeds with different assumed levels of trypanotolerance. The objectives were (i) to identify molecular signatures of selection related to trypanotolerance; and (ii) to guide an optimal sampling for subsequent studies. From 33 identified signatures, 18 had been detected previously in the literature as being mainly associated with climatic adaptations. The most plausible signatures of trypanotolerance indicate the genes