AUTHOR=Zheng Peng-Fei , Yin Rui-Xing , Cao Xiao-Li , Guan Yao-Zong , Deng Guo-Xiong , Wei Bi-Liu , Liu Chun-Xiao 

TITLE=SYTL3–SLC22A3 Single-Nucleotide Polymorphisms and Gene–Gene/Environment Interactions on the Risk of Hyperlipidemia

JOURNAL=Frontiers in Genetics

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.679027

DOI=10.3389/fgene.2021.679027

ISSN=1664-8021

ABSTRACT=<p>The current study aims to further delineate the associations between the synaptotagmin-like 3 (<italic>SYTL3</italic>) and solute carrier family 22 member 3 (<italic>SLC22A3</italic>) single-nucleotide polymorphisms (SNPs) and their haplotypes and gene–gene (G × G)/environment (G × E) interactions on the risk of hyperlipidemia (HLP) in the Maonan and Han ethnic groups. Genotype distribution among the <italic>SYTL3–SLC22A3</italic> SNPs in 2,829 individual patients bearing no relationship to each other (Han, 1,436; Maonan, 1,393) was analyzed utilizing next-generation sequencing techniques. The genotype frequencies of the rs6455600, rs2129209, and rs446809 SNPs were varied between the two ethnic groups (<italic>P</italic> &lt; 0.05–0.001). Various SNPs were correlated with serum levels of triglyceride (TG; rs446809), total cholesterol (TC; rs6455600, rs2129209, and rs539298), and low-density lipoprotein cholesterol (LDL-C; rs446809) among the Han population, whereas various SNPs were also correlated with TC (rs6455600 and rs539298), TG (rs446809), and LDL-C (rs446809) levels in the Maonan ethnic group (<italic>P</italic> &lt; 0.008–0.001). One part of haplotypes resulted in worsened HLP-related morbidity in the Han (<italic>SYTL3</italic> A-C-A-A; <italic>SLC22A3</italic> A-A and A-G; and <italic>SYTL3–SLC22A3</italic> A-C-A-A-A-A and A-C-A-A-A-G) and Maonan (<italic>SYTL3</italic> A-C-A-A; <italic>SLC22A3</italic> A-A and A-G; and <italic>SYTL3–SLC22A3</italic> A-C-A-A-A-A, G-T-C-A-A-A, and G-T-C-A-C-A) ethnic groups, whereas another part of haplotypes lowered HLP-related health risks in the Han (<italic>SLC22A3</italic> C-A and C-G and <italic>SYTL3–SLC22A3</italic> A-C-A-A-C-A, A-C-A-A-C-G, and G-T-C-A-C-A) and Maonan (<italic>SLC22A3</italic> C-G and <italic>SYTL3–SLC22A3</italic> A-C-A-A-C-G) ethnic groups. We discovered that the <italic>SYTL3–SLC22A3</italic> SNPs and their haplotypes were associated with serum lipid levels and the risk of HLP in our studied populations.</p>