AUTHOR=Pian Cong , Yang Zhixin , Yang Yuqian , Zhang Liangyun , Chen Yuanyuan TITLE=Identifying RNA N6-Methyladenine Sites in Three Species Based on a Markov Model JOURNAL=Frontiers in Genetics VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.650803 DOI=10.3389/fgene.2021.650803 ISSN=1664-8021 ABSTRACT=
N6-methyladenosine (m6A), the most common posttranscriptional modification in eukaryotic mRNAs, plays an important role in mRNA splicing, editing, stability, degradation, etc. Since the methylation state is dynamic, methylation sequencing needs to be carried out over different time periods, which brings some difficulties to identify the RNA methyladenine sites. Thus, it is necessary to develop a fast and accurate method to identify the RNA N6-methyladenosine sites in the transcriptome. In this study, we use first-order and second-order Markov models to identify RNA N6-methyladenine sites in three species (