AUTHOR=Lu Minqiu , Wu Yin , Gao Wen , Tian Ying , Wang Guorong , Liu Aijun , Chen Wenming TITLE=Novel Non-coding RNA Analysis in Multiple Myeloma Identified Through High-Throughput Sequencing JOURNAL=Frontiers in Genetics VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.625019 DOI=10.3389/fgene.2021.625019 ISSN=1664-8021 ABSTRACT=
This study aimed to explore the potential effects of novel non-coding ribose nucleic acids (ncRNAs) in patients with multiple myeloma (MM). The gene expression profile of plasma cells was used for sequence analysis to explore the expression pattern of ncRNAs in MM. The expression patterns of non-coding RNAs in MM were analyzed by RNA sequencing (whole-transcriptome-specific RNA sequencing). Next, the expression of the selected ncRNAs was verified by quantitative real-time polymerase chain reaction. Further, the lncRNA-associated competitive endogenous RNA network in MM was elucidated using deep RNA-seq. Differentially expressed (DE) ncRNAs were significantly regulated in patients with MM. DE target lncRNAs were analyzed by