AUTHOR=Zeng Qiaoli , Chen Qikang , Zou Dehua , Guo Runmin , Xiao Dawei , Jiang Shaohu , Chen Riling , Wang Yajun , Ma Guoda 

TITLE=Different Associations Between the IREB2 Variants and Chronic Obstructive Pulmonary Disease Susceptibility

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.598053

DOI=10.3389/fgene.2020.598053

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Iron responsive element binding protein 2 (<italic>IREB2</italic>) variants may be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recently, many studies have been performed on <italic>IREB2</italic> susceptibility variants, including rs2568494, rs2656069, rs10851906, rs12593229, and rs13180, associated with COPD. However, inconsistent findings have been reported. The aim of our research was to determine the association of <italic>IREB2</italic> SNPs with COPD.</p><p><bold>Methods:</bold> A comprehensive meta-analysis was performed to accurately estimate the association between <italic>IREB2</italic> variants and COPD among four different genetic models.</p><p><bold>Results:</bold> This meta-analysis included a total of 4,096 patients and 5,870 controls. Here, we investigated the 5 <italic>IREB2</italic> variants to identify COPD risk. Our results indicate that rs2568494 was associated with an increased risk of COPD for the dominant model (AA+GA vs. GG: OR = 1.150, 95% CI: 1.5–1.304, <italic>P</italic> = 0.029); rs2656069 was associated with a decreased risk of COPD for the recessive model (GG vs. AA+AG: OR = 0.589, 95% CI: 0.440–0.789; <italic>P</italic> = 0.000), additive model (GG vs. AA: OR =0.641, 95% CI: 0.441–0.931; <italic>P</italic> = 0.020), and allele model (G vs. A: OR = 0.812, 95% CI: 0.668–0.988; <italic>P</italic> = 0.037); and rs10851906 was associated with a decreased risk of COPD for the recessive model (GG vs. AA+AG: OR = 0.732, 95% CI: 0.560–0.958; <italic>P</italic> = 0.023) and additive model (GG vs. AA: OR = 0.777, 95% CI: 0.637–0.947; <italic>P</italic> = 0.012).</p><p><bold>Conclusion:</bold> Our findings suggest that the <italic>IREB2</italic> rs2568494 minor alleles A may be a genetic factor in susceptibility to COPD. In addition, the minor alleles G of rs2656069 and rs10851906 appear to have a protective effect.</p>