AUTHOR=Hankey William , Zanghi Nicholas , Crow Mackenzie M. , Dow Whitney H. , Kratz Austin , Robinson Ashley M. , Robinson Meaghan R. , Segarra Verónica A. TITLE=Using The Cancer Genome Atlas as an Inquiry Tool in the Undergraduate Classroom JOURNAL=Frontiers in Genetics VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.573992 DOI=10.3389/fgene.2020.573992 ISSN=1664-8021 ABSTRACT=

Undergraduate students in the biomedical sciences are often interested in future health-focused careers. This presents opportunities for instructors in genetics, molecular biology, and cancer biology to capture their attention using lab experiences built around clinically relevant data. As biomedical science in general becomes increasingly dependent on high-throughput data, well-established scientific databases such as The Cancer Genome Atlas (TCGA) have become publicly available tools for medically relevant inquiry. The best feature of this database is that it bridges the molecular features of cancer to human clinical outcomes—allowing students to see a direct connection between the molecular sciences and their future professions. We have developed and tested a learning module that leverages the power of TCGA datasets to engage students to use the data to generate and test hypotheses and to apply statistical tests to evaluate significance.