AUTHOR=Zhao Lihong , Han Guanghong , Zhao Yinghao , Jin Yang , Ge Tongtong , Yang Wei , Cui Ranji , Xu Songbai , Li Bingjin 

TITLE=Gender Differences in Depression: Evidence From Genetics

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.562316

DOI=10.3389/fgene.2020.562316

ISSN=1664-8021

ABSTRACT=<p>Compared with men, female accounts for a larger proportion of patients with depression. Behavioral genetics researches find gender differences in genetic underpinnings of depression. We found that gender differences exist in heritability and the gene associated with depression after reviewing relevant research. Both genes and gene-environment interactions contribute to the risk of depression in a gender-specific manner. We detailed the relationships between serotonin transporter gene-linked promoter region (5-HTTLPR) and depression. However, the results of these studies are very different. We explored the reasons for the contradictory conclusions and provided some suggestions for future research on the gender differences in genetic underpinnings of depression.</p>