AUTHOR=Wang Yanchao , Gao Luyan , Lang Wenjing , Li He , Cui Pan , Zhang Nan , Jiang Wei 

TITLE=Serum Calcium Levels and Parkinson’s Disease: A Mendelian Randomization Study

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00824

DOI=10.3389/fgene.2020.00824

ISSN=1664-8021

ABSTRACT=<sec><title>Background</title><p>Though increasing epidemiological studies have evaluated the correlation between serum calcium contents and Parkinson’s disease (PD), the results are inconsistent. At present, whether there is a causal association between serum calcium content and PD remains undetermined.</p></sec><sec><title>Objective and Methods</title><p>This study was designed to explore the relationship between increased serum calcium contents and PD risk. In this present study, a Mendelian randomization trial was carried out using a large-scale serum calcium genome-wide association study (GWAS) dataset (<italic>N</italic> = 61,079, Europeans) and a large-scale PD GWAS dataset (<italic>N</italic> = 8,477, Europeans including 4,238 PD patients and 4,239 controls). Here, a total of four Mendelian randomization methods comprising weighted median, inverse-variance weighted meta-analysis (IVW), MR-Egger, and MR-PRESSO were used.</p></sec><sec><title>Results</title><p>Our data concluded that genetically higher serum calcium contents were not significantly related to PD.</p></sec><sec><title>Conclusion</title><p>In conclusion, we provided genetic evidence that there was no direct causal relationship between serum calcium contents and PD. Hence, calcium supplementation may not result in reduced PD risk.</p></sec>