AUTHOR=Sun Peisen , Wang Haoming , Li Guanglin 

TITLE=Rcirc: An R Package for circRNA Analyses and Visualization

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00548

DOI=10.3389/fgene.2020.00548

ISSN=1664-8021

ABSTRACT=<p>Circular RNA (circRNA), which has a closed-loop structure, is a special type of endogenous RNA that plays important roles in many biological processes. With improvements in next-generation sequencing technology and bioinformatics methods, some tools have been published for circRNA detection based on RNA-seq. Here, we developed the R package “Rcirc” for further analyses of circRNA after its detection. Rcirc identifies the coding ability of circRNA and visualizes various aspects of this feature. It also provides general visualization for both single circRNAs and meta-features of thousands of circRNAs. Rcirc was designed as a user-friendly tool that provides many highly automated functions without requiring the user to perform many complicated processes. It is available on GitHub (<ext-link xlink:href="https://github.com/PSSUN/Rcirc" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">https://github.com/PSSUN/Rcirc</ext-link>) under the license GPL 3.0.</p>