AUTHOR=Yang Haojie , Jin Wei , Liu Hua , Gan Dan , Cui Can , Han Changpeng , Wang Zhenyi 

TITLE=Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00401

DOI=10.3389/fgene.2020.00401

ISSN=1664-8021

ABSTRACT=<p>Mounting evidence supports that the malignant phenotypes of cancers are defined not only by the intrinsic activity of tumor cells but also by immune cells that are recruited and activated in tumor-related microenvironment. Here, we developed a diagnostic and prognostic model for colon cancer, based on expression profiles of immune-related genes and immune cell component. As a result, we found that B cell infiltration ratio, CD4<sup>+</sup> T cells, as well as immune-related genes of <italic>TRIB3</italic>, <italic>CHGA</italic>, <italic>CASP7</italic>, <italic>LGALS4</italic>, <italic>LEP</italic>, <italic>NOX4</italic>, <italic>IL17A</italic>, and <italic>HSPD1</italic> may be highly relevant with clinical outcome of colon cancer.</p>