AUTHOR=Tao Xuefang , Wu Xiaotang , Huang Tao , Mu Deguang 

TITLE=Identification and Analysis of Dysfunctional Genes and Pathways in CD8+ T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00352

DOI=10.3389/fgene.2020.00352

ISSN=1664-8021

ABSTRACT=<p>Lung cancer, the most common of malignant tumors, is typically of the non-small cell (NSCLC) type. T-cell-based immunotherapies are a promising and powerful approach to treating NSCLCs. To characterize the CD8<sup>+</sup> T cells of non-small cell lung cancer, we re-analyzed the published RNA-Seq gene expression profiles of 36 CD8<sup>+</sup> T cell isolated from tumor (TIL) samples and 32 adjacent uninvolved lung (NTIL) samples. With an advanced Monte Carlo method of feature selection, we identified the CD8<sup>+</sup> TIL specific expression patterns. These patterns revealed the key dysfunctional genes and pathways in CD8<sup>+</sup> TIL and shed light on the molecular mechanisms of immunity and use of immunotherapy.</p>