AUTHOR=Chen Guangyuan , Hu Cong , Song Yuxuan , Xiu Mengxi , Liang Wanfeng , Ou Ningjing , Liu Xiaoqiang , Huang Peng 

TITLE=Relationship Between the ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), and TaqI (rs731236) Variants in the Vitamin D Receptor Gene and Urolithiasis Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis

JOURNAL=Frontiers in Genetics

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00234

DOI=10.3389/fgene.2020.00234

ISSN=1664-8021

ABSTRACT=<p>The relationship between urolithiasis and vitamin D receptor (VDR) gene variants is still under debate according to the available published literature. To assess correlations between <italic>VDR</italic> gene variants <italic>ApaI</italic> (rs7975232), <italic>BsmI</italic> (rs1544410), <italic>FokI</italic> (rs2228570), and <italic>TaqI</italic> (rs731236) and urolithiasis susceptibility, we performed the present study through meta-analysis. The PubMed, Cochrane Library, China National Knowledge Infrastructure, EMBASE, Web of Science, and Wanfang databases were searched to retrieve qualified case-control studies. Finally, 31 reports were selected for the present meta-analysis. The results demonstrated that the <italic>VDR</italic> gene <italic>TaqI</italic> TT genotype was related to decreased risk of urolithiasis in the overall population (TT vs. Tt+tt: <italic>P</italic> = 0.011, OR = 0.824, 95% CI = 0.709–0.957). In ethnicity subgroup analysis, we found that the <italic>TaqI</italic> variant was obviously correlated to urolithiasis risk among Asians and Caucasians (<italic>P</italic> &lt; 0.05). Additionally, significant urolithiasis risk was identified in adults. However, the <italic>FokI, BsmI</italic>, and <italic>ApaI</italic> variants did not have an increased risk of developing urolithiasis. Trial sequential analysis results were on a sufficiently large number of participants and did not require more research to confirm associations. Our research suggested that the <italic>VDR</italic> gene variant <italic>TaqI</italic> was correlated with urolithiasis susceptibility and that the t-allele might be the risk gene and T-allele the protective gene in <italic>VDR TaqI</italic> variant.</p>